Many proteins and signaling pathways are present in most cell types and tissues and yet perform specialized functions. To elucidate mechanisms by which these ubiquitous pathways are modulated. we overlaid information about cross-cell line protein abundance and variability. and evolutionary conservation onto functional pathway components and topological layers in the pathway hierarchy. https://www.balboasurfandsstylers.shop/product-category/little-girls-l-s-onesie/