The current COVID-19 pandemic is motivating us to elucidate the molecular mechanism of SARS-CoV-2 invasion and find methods for decreasing its transmissibility. We found that SARS-CoV-2 could increase the protein level of ACE2 in mice. Folic acid and 5-10-methylenetetrahydrofolate reductase (MTHFR) could promote the methylation of the ACE2 promoter and inhibit ACE2 expression. https://www.hindigyanvishv.com/super-save-Smart-Tv-Led-32-Hd-Panasonic-32fs500b-2-Hdmi-2-Usb-Wi-fi-Conversor-Digital-super-buy/